Volume 13, Issue 4 (Winter 2019)
Salmand: Iranian Journal of Ageing 2019, 13(4): 494-505 |
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1- Department of Physiology, Faculty of Physical Education and Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
2- Department of Physiology, Faculty of Physical Education and Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. , mfathei@um.ac.ir
3- Department of Physiology, Faculty of Humanities, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
2- Department of Physiology, Faculty of Physical Education and Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran. , mfathei@um.ac.ir
3- Department of Physiology, Faculty of Humanities, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran.
Abstract: (5420 Views)
Objectives Ghrelin is a peptide hormone secreted from the endocrine cells of stomach, affecting feeding behavior, appetite, energy consumption, and body weight. The present study compared the effect of 8 weeks of aerobic training on plasma ghrelin and lymphocyte ghrelin gene expression in elderly men.
Methods & Materials In this quasi-experimental study, 30 subjects were selected by convenience sampling method. They were randomly divided into 2 equal groups of aerobic training (n=15) and control (n=15). Aerobic training program included aerobic trainings up to 50-60 minutes at 60-85% of the maximum heart rate, 4 sessions per week which lasted for 8 weeks. After initial assessments (body composition and ghrelin gene expression), followed by 8 weeks of exercise training, post-intervention assessments were completed 48 hours after the last training session. To make intra- and between-group comparisons, repeated measures Analysis of Variance (ANOVA) was used. For all statistical comparisons, the level of significance was set at P<0.05.
Results The Mean±SD age ranges of the study participants were 69.13±3.68 years in the training group and 69.20±4.31 in the control group. Eight weeks of aerobic training significantly reduced BMI from 27.57 to 26.90 kg/m2 (P=0.001), and body fat percentage from 24.31% to 21.43% (P=0.001) in the training group. In addition, lymphocyte ghrelin gene expression significantly increased from 16.87% to 24.92% in the aerobic training group. There was no significant changes in plasma ghrelin levels.
Conclusion Aerobic training through increasing the lymphocyte ghrelin gene expression level and decreasing the values of BMI in middle-aged men, can prevent the incidence of obesity and overweight. It is reasonable to support the role of physical activity as a non-prescriptive therapy in regulating balance and effective peptide hormones in the prevalence of obesity. Therefore, aerobic exercises can be used as a preventive method for the reduction of obesity and the incidence of related diseases.
Methods & Materials In this quasi-experimental study, 30 subjects were selected by convenience sampling method. They were randomly divided into 2 equal groups of aerobic training (n=15) and control (n=15). Aerobic training program included aerobic trainings up to 50-60 minutes at 60-85% of the maximum heart rate, 4 sessions per week which lasted for 8 weeks. After initial assessments (body composition and ghrelin gene expression), followed by 8 weeks of exercise training, post-intervention assessments were completed 48 hours after the last training session. To make intra- and between-group comparisons, repeated measures Analysis of Variance (ANOVA) was used. For all statistical comparisons, the level of significance was set at P<0.05.
Results The Mean±SD age ranges of the study participants were 69.13±3.68 years in the training group and 69.20±4.31 in the control group. Eight weeks of aerobic training significantly reduced BMI from 27.57 to 26.90 kg/m2 (P=0.001), and body fat percentage from 24.31% to 21.43% (P=0.001) in the training group. In addition, lymphocyte ghrelin gene expression significantly increased from 16.87% to 24.92% in the aerobic training group. There was no significant changes in plasma ghrelin levels.
Conclusion Aerobic training through increasing the lymphocyte ghrelin gene expression level and decreasing the values of BMI in middle-aged men, can prevent the incidence of obesity and overweight. It is reasonable to support the role of physical activity as a non-prescriptive therapy in regulating balance and effective peptide hormones in the prevalence of obesity. Therefore, aerobic exercises can be used as a preventive method for the reduction of obesity and the incidence of related diseases.
Type of Study: Research |
Subject:
General
Received: 2018/06/13 | Accepted: 2018/11/10 | Published: 2019/01/01
Received: 2018/06/13 | Accepted: 2018/11/10 | Published: 2019/01/01
References
1. Cheng MH, Bushnell D, Cannon DT, Kern M. Appetite regulation via exercise prior or subsequent to high-fat meal consumption. Appetite. 2009; 52(1):193-8. [DOI:10.1016/j.appet.2008.09.015] [DOI:10.1016/j.appet.2008.09.015]
2. Issazadeh R. Effect of twelve weeks combined exercise (aerobicresistance) on plasma levels of ghrelin and obestatin in obese adolescens. Razi Journal of Medical Sciences. 2016; 22(141):91-103.
3. Cummings DE. Ghrelin and the short-and long-term regulation of appetite and body weight. Physiology & Behavior. 2006; 89(1):71-84. [DOI:10.1016/j.physbeh.2006.05.022] [DOI:10.1016/j.physbeh.2006.05.022]
4. Cummings DE, Shannon MH. Roles for ghrelin in the regulation of appetite and body weight. Archives of Surgery. 2003; 138(4):389-96. [DOI:10.1001/archsurg.138.4.389] [DOI:10.1001/archsurg.138.4.389]
5. Ukkola O, Ravussin E, Jacobson P, Snyder EE, Chagnon M, Sjöström L, Bouchard C. Rapid communications: Mutations in the preproghrelin/ghrelin gene associated with obesity in humans. The Journal of Clinical Endocrinology & Metabolism. 2001; 86(8):3996-9. [DOI:10.1210/jcem.86.8.7914] [PMID] [DOI:10.1210/jcem.86.8.7914]
6. Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, et al. Ghrelin is present in pancreatic α-cells of humans and rats and stimulates insulin secretion. Diabetes. 2002; 51(1):124-9. [DOI:10.2337/diabetes.51.1.124] [DOI:10.2337/diabetes.51.1.124]
7. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. Ghrelin—a hormone with multiple functions. Frontiers in neuroendocrinology. 2004; 25(1):27-68. [DOI:10.1016/j.yfrne.2004.03.002] [PMID]
8. Woods SC, Benoit SC, Clegg DJ, Seeley RJ. Regulation of energy homeostasis by peripheral signals. Best Practice & Research Clinical Endocrinology & Metabolism. 2004; 18(4):497-515. [DOI:10.1016/j.beem.2004.08.004] [DOI:10.1016/j.beem.2004.08.004]
9. Banks E, Lim L, Seubsman SA, Bain C, Sleigh A. Relationship of obesity to physical activity, domestic activities, and sedentary behaviours: cross-sectional findings from a national cohort of over 70,000 Thai adults. BMC Public Health. 2011; 11:762. [DOI:10.1186/1471-2458-11-762] [DOI:10.1186/1471-2458-11-762]
10. Kraemer RR, Castracane VD. Exercise and humoral mediators of peripheral energy balance: Ghrelin and adiponectin. Experimental Biology and Medicine. 2007; (2):184-94.
11. Olcucu B, Vatansever S, Koparan S, Mulazimoglu O, Çınar V. Effect of moderate intensity exercise on ghrelin and leptin hormones. Life Sciences. 2015; 5(3):1301-6.
12. Azizi M. Serum leptin and ghrelin changes-induced aerobic training in healthy young females. International Journal of Collaborative Research on Internal Medicine & Public Health. 2012; 4(6):1257-64.
13. Sternfeld B, Ainsworth BE, Quesenberry JR CP. Physical activity patterns in a diverse population of women. Preventive Medicine. 1999; 28(3):313-23. [DOI:10.1006/pmed.1998.0470] [DOI:10.1006/pmed.1998.0470]
14. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999; 402(6762):656-60. [DOI:10.1038/45230] [DOI:10.1038/45230]
15. Aghapour A, Farzanegi P. Effect of six-week aerobic exercise on Chemerin and Resistin concentration in hypertensive postmenopausal women. Electronic Physician. 2013; 5(1):623-30. [PMID] [PMCID]
16. Fathi R, Ghanbari-Niaki A, Rahbarizadeh F, Hedayati MA, Ghahramanloo E, et al. The effect of exercise on plasma acylated ghrelin concentrations and gastrocnemius muscle mRNA expression in male rats. Iranian Journal of Endocrinology and Metabolism. 2009; 10(5):519-26.
17. Nuri R, Moghaddasi M, Darvishi H, Izadpanah A. Effect of aerobic exercise on leptin and ghrelin in patients with colorectal cancer. Journal of Cancer Research and Therapeutics. 2016; 12(1):169-74. [DOI:10.4103/0973-1482.155982] [DOI:10.4103/0973-1482.155982]
18. Parvizi A, Ghasemnian A, Rahmani A. [Effect of 12 weeks aerobic exercise for along with folic acid supplementation on the levels of the ghrelin hormone amount of food intake and weight changes of female Wistar rats (Persian)]. Armaghan-e Danesh. 2016; 21(8):746-56.
19. Keikhosravi F, Shah HM, Daryanoush F, Hosseini SA, Noura M, Hasanpour G, et al. The effect of eight weeks moderate Intensity aerobic training on obestatin and ghrelin of obese male rats. Researcher in Sport Science Quarterly. 2011; 2(1):18-25.
20. Ghelardoni S, Carnicelli V, Frascarelli S, Ronca-Testoni S, Zucchi R. Ghrelin tissue distribution: comparison between gene and protein expression. Journal of Endocrinological Investigation. 2006; 29(2):115-21. [DOI:10.1007/BF03344083] [DOI:10.1007/BF03344083]
21. Morpurgo PS, Resnik M, Agosti F, Cappiello V, Sartorio A, Spada A. Ghrelin secretion in severely obese subjects before and after a 3-week integrated body mass reduction program. Journal of Endocrinological Investigation. 2003; 26(8):723-7. [DOI:10.1007/BF03347353] [PMID]
22. Chen JX, Zhao X, Yue GX, Wang ZF. Influence of acute and chronic treadmill exercise on rat plasma lactate and brain NPY, LENK, DYN A 1–13. Cellular and Molecular Neurobiology. 2007; 27(1):1-10. [DOI:10.1007/s10571-006-9110-4] [DOI:10.1007/s10571-006-9110-4]
23. Hansen TK, Dall R, Hosoda H, Kojima M, Kangawa K, Christiansen JS, et al. Weight loss increases circulating levels of ghrelin in human obesity. Clinical Endocrinology. 2002; 56(2):203-6. [DOI:10.1046/j.0300-0664.2001.01456.x] [DOI:10.1046/j.0300-0664.2001.01456.x]
24. Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes. 2001; 50(4):707-9. [DOI:10.2337/diabetes.50.4.707] [DOI:10.2337/diabetes.50.4.707]
25. Tolle V, Kadem M, Bluet-Pajot MT, Frere D, Foulon C, Bossu C, et al. Balance in ghrelin and leptin plasma levels in anorexia nervosa patients and constitutionally thin women. The Journal of Clinical Endocrinology & Metabolism. 2003; 88(1):109-16. [DOI:10.1210/jc.2002-020645] [DOI:10.1210/jc.2002-020645]
26. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, et al. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. The Journal of Clinical Endocrinology & Metabolism. 2002; 87(1):240-4. [DOI:10.1210/jcem.87.1.8129] [DOI:10.1210/jcem.87.1.8129]
27. Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, et al. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 2008; 454(7206):846-51. [DOI:10.1038/nature07181] [DOI:10.1038/nature07181]
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