Volume 16, Issue 3 (Autumn 2021)                   Salmand: Iranian Journal of Ageing 2021, 16(3): 452-467 | Back to browse issues page


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Miri L, Foroughan M, Vahedi M, Shahbazi A. The Relationships Between Daily Sleepiness and Cardiovascular Health Indicators in the Older Adults. Salmand: Iranian Journal of Ageing 2021; 16 (3) :452-467
URL: http://salmandj.uswr.ac.ir/article-1-2067-en.html
1- Department of Gerontology, Genetics Research Center, Faculty of Educational Sciences and Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
2- Department of Gerontology, Genetics Research Center, Faculty of Educational Sciences and Social Welfare, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. , m_foroughan@yahoo.com
3- Department of Biostatistics and Epidemiology, Genetics Research Center, Faculty of Rehabilitation, Faculty of Rehabilitation, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
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1. Introduction
Extensive studies have been conducted in the world to identify the factors associated with cardiovascular disease. Some studies have suggested the role of sleep disorders, including daytime drowsiness, in cardiovascular disease [12]. Overall, studies have confirmed the association between drowsiness and cardiovascular indicators, but there is disagreement about which of these indicators is associated with daily drowsiness and how it is related. Studies on the relationship between daily drowsiness and cardiovascular indices have been performed mainly on a limited group of patients and the study on the general elderly population has been small. Considering that daily drowsiness is one of the most common disorders in the elderly, in this study we aimed to investigate the relationship between daily drowsiness and cardiovascular health indicators in a group of the general Iranian elderly population.
2. Materials and Methods
321 elderly people covered by health centers of Kiar city in Chaharmahal and Bakhtiari province participated in this cross-sectional study using available sampling from all centers. Inclusion criteria include age 60 years and older, willingness to participate in research, no severe cognitive and psychological disorders, ability to communicate verbally; Exclusion criteria included the use of any psychedelic or hypnotic drug, incomplete completion of the questionnaire, refusal to perform or perform incomplete tests, acute illness and any other diseases affecting mental function and alertness and test results. Data were collected using demographic characteristics questionnaire, Epworth Excessive Sleepiness Scale (ESS), Measurement of anthropometric indices, and paraclinical tests. Among anthropometric indices, body mass index BM (BMI) in three normal groups (24.9-18.5), overweight (25-29.9), obesity (30 and more), waist circumference (As an indicator of abdominal obesity equal to or greater than 88 cm in women and equal to or greater than 102 cm in men), neck circumference (as an indicator of cervical obesity equal to 37 cm and above in men and 34 cm and above in women) and blood pressure (systolic blood pressure 140 mmHg and above and diastolic blood pressure 90 mmHg and above as high blood pressure) were measured. Paraclinical data include measurement of fasting blood sugar (110 mg and above as high blood sugar), triglyceride (150 mg / dL and above as high triglyceride), and cholesterol (200 mg / dL and above as high cholesterol) were also collected. The cut-off point for distinguishing drowsiness of clinical significance was considered in the Opworth questionnaire 10 [3, 4]. To analyze the data, SPSS v. 23 statistical software, descriptive statistics, and Chi-square, Mann-Whitney, Kruskal-Wallis, and Spearman correlation coefficients were used. This study has an ethics code, IR.USWR.REC.1398.102 from the Medical Ethics Committee of the University of Rehabilitation Sciences and Social Health.
3. Results
The mean age of the sampled elderly was 68.7 years with a standard deviation of 7.28 and 69.2% of them were women and 76.6% of them were married. Also, most of the participants were unemployed or housewives (76%) and 77.3% were illiterate. The history of cardiovascular disease and physical disease were 20.9% and 32.1%, respectively. More than 55% had a history of hypertension and 7.8% had a history of smoking. The participant's body mass index in the normal range, overweight, and obesity were 31.8%, 39.9%, and 28.3%, respectively. In 69.2% of the study population, waist circumference was in the abnormal range; Also, 62% had abnormal neck circumference; Systolic and diastolic hypertension were also reported to be 19.3% and 16.2%, respectively. 21.8% of the blood sugar sample was abnormal and 76.3% and 38.9% had abnormal cholesterol and triglyceride levels, respectively.
The results showed that 23.67, 19 and 7% of the elderly had mild to severe drowsiness, respectively, and there was a significant relationship between daily drowsiness and age (p=0.03, r=0.121). Age over 70 years was significantly associated with high ESS scores (P=0.003) and also between daily drowsiness and body mass index (r=0.172, p=0.002), systolic blood pressure (r=0.235, p<0.001) and diastolic blood pressure (r=0.216, p<0.001), abdominal obesity (r=0.293, p<0.001) and neck circumference (r=0.239, p<0.001), a significant positive correlation was observed. The relationship between daily drowsiness and the number of drugs used was also significant and positive (p<0.001, r=0.226). But other variables such as triglyceride (p=0.374), cholesterol (p=0.824), and fasting blood sugar (p=0.084) were not significantly associated with daily drowsiness. Comparison of the mean score of drowsiness between men and women did not show a significant difference (P=0.158). In addition, a comparison of the two groups with and without drowsiness (based on cut-off point 10) showed that there was a significant difference between drowsiness with body mass index (p=0.003), history of hypertension (p≤0.001), high systolic blood pressure (0.015), diastolic blood pressure (p=0.002), fasting blood sugar (p≤0.001), and neck circumference (p=0.002) between the two groups.
4. Discusion and Conclusion
This study confirmed the relationship between daily drowsiness and some indicators of cardiovascular health including body mass index, hypertension, abdominal obesity, and neck circumference. It also showed that fasting blood sugar levels were significantly different between the two groups with and without daily drowsiness. The high prevalence of daily drowsiness in the elderly and the results of other research on the relationship between daily drowsiness and cardiovascular disease warns the need for further study on daily drowsiness in the elderly, how to measure and study its causes, and design and implementation of preventive interventions. It is recommended that daily drowsiness assessments be performed in routine care programs for the elderly, especially the elderly with cardiovascular disease, to detect both disorders early and reduce the rate of both disorders. It is also suggested that the cardiovascular condition in patients with daily drowsiness and vice versa be considered.

Ethical Considerations
Compliance with ethical guidelines

This study was approved by the Ethics Committee of the University of Social Welfare and Rehabilitation Sciences (Code: IR.USWR.REC.1398.102). All ethical principles are considered in this article. The participants were informed about the purpose of the research and its implementation stages. They were also assured about the confidentiality of their information. They were free to leave the study whenever they wished, and if desired, the research results would be available to them.

Funding
This research did not receive any grant from funding agencies in the public, commercial, or non-profit sectors. 

Authors' contributions
All authors equally contributed to preparing this article.

Conflicts of interest
The authors declared no conflict of interest.


References
  1. Sheldon SH, Ferber R, Kryger MH. Principles and practice of pediatric sleep medicine. Philadelphia: Saunders; 2005. https://www.google.com/books/edition/Principles_and_Practice_of_Pediatric_Sle/0EGsy3bUCYwC?hl=en&gbpv=0
  2. Mendoza-Meléndez M, Jimenez-Correa U, Gallegos-Cari A, Ayala-Guerrero F, Jiménez-Anguiano A. Prevalence of sleep disorders, daytime sleepiness and clinical symptomatology in older adults. Journal of Revista Médica del Hospital General de México. 2016; 79(3):136-43. [DOI:10.1016/j.hgmx.2016.05.021]
  3. Miner B, Kryger MH. Sleep in the aging population. Sleep Medicine Clinics. 2017; 12(1):31-8. [DOI:10.1016/j.jsmc.2016.10.008] [PMID] [PMCID]
  4. Kim KW, Kang SH, Yoon IY, Lee SD, Ju G, Han JW, et al. Prevalence and clinical characteristics of insomnia and its subtypes in the Korean elderly. Archives of Gerontology and Geriatrics. 2017; 68:68-75. [DOI:10.1016/j.archger.2016.09.005] [PMID]
  5. Korkmaz Aslan G, İncİ FH, Kartal A. The prevalence of insomnia and its risk factors among older adults in a city in Turkey’s Aegean Region. Psychogeriatrics. 2020; 20(1):111-7. [DOI:10.1111/psyg.12464] [PMID]
  6. Zou Y, Chen Y, Yu W, Chen T, Tian Q, Tu Q, et al. The prevalence and clinical risk factors of insomnia in the Chinese elderly based on comprehensive geriatric assessment in Chongqing population. Psychogeriatrics. 2019; 19(4):384-90. [DOI:10.1111/psyg.12402] [PMID]
  7. Young TB. Epidemiology of daytime sleepiness: Definitions, symptomatology, and prevalence. The Journal of Clinical Psychiatry. 2004; 65(Suppl 16):12-6. [PMID]
  8. Sateia MJ. International classification of sleep disorders-third edition. Chest. 2014; 146(5):1387-94. [DOI:10.1378/chest.14-0970][PMID]
  9. Aghajanloo A, Haririan HR, Ghafourifard M, Bagheri H, Ebrahimi SM. [Sleep quality of students during final exams in Zanjan University of Medical Sciences (Persian)]. Modern Care Journal. 2012; 8(4):230-7. https://www.sid.ir/fa/journal/ViewPaper.aspx?id=157520
  10. Zalai D, Bingeliene A, Shapiro C. Sleepiness in the elderly. Sleep Medicine Clinics. 2017; 12(3):429-41. [DOI:10.1016/j.jsmc.2017.03.015] [PMID]
  11. Pagel JF. Excessive daytime sleepiness. American Family Physician. 2009; 79(5):391-6. [PMID]
  12. Pakpour V, Zamanzadeh V, Salimi S, Farsiv A, Moghbeli G, Soheili A. [The relationship between loneness and sleep quality in older adults in Tabriz (Persian)]. Nursing and Midwifery Journal. 2017; 14(11):906-17. http://unmf.umsu.ac.ir/article-1-3060-en.html
  13. Hayley AC, Williams LJ, Kennedy GA, Holloway KL, Berk M, Brennan-Olsen SL, et al. Excessive daytime sleepiness and falls among older men and women: Cross-sectional examination of a population-based sample. BMC Geriatrics. 2015; 15:74. [DOI:10.1186/s12877-015-0068-2] [PMID] [PMCID]
  14. Bixler EO, Vgontzas AN, Lin HM, Calhoun SL, Vela-Bueno A, Kales A. Excessive daytime sleepiness in a general population sample: The role of sleep apnea, age, obesity, diabetes, and depression. The Journal of Clinical Endocrinology and Metabolism. 2005; 90(8):4510-5. [DOI:10.1210/jc.2005-0035] [PMID]
  15. Ng WL, Shaw JE, Peeters A. The relationship between excessive daytime sleepiness, disability, and mortality, and implications for life expectancy. Sleep Medicine. 2018; 43:83-9. [DOI:10.1016/j.sleep.2017.11.1132] [PMID]
  16. Prasad BV, Akbar Sh, R A. Cardiovascular disease in elderly an early care: Biopsychosocial perspective. In: Prasad BV, Akbar Sh, editors. Handbook of Research on Geriatric Health, Treatment, and Care. Hershey, PA: IGI Global; 2018. pp. 175-193. [DOI:10.4018/978-1-5225-3480-8.ch010]
  17. Chen WW, Gao RL, Liu LS, Zhu ML, Wang W, Wang YJ, et al. China cardiovascular diseases report 2015: A summary. Journal of Geriatric Cardiology. 2017; 14(1):1-10. [PMID] [PMCID]
  18. Keeney T, Jette AM. Individual and environmental determinants of late-life community disability for persons aging with cardiovascular disease. American Journal of Physical Medicine & Rehabilitation. 2019; 98(1):30-4. [DOI:10.1097/PHM.0000000000001011] [PMID] [PMCID]
  19. Leong DP, Joseph PG, McKee M, Anand SS, Teo KK, Schwalm JD, et al. Reducing the global burden of cardiovascular disease, part 2: Prevention and treatment of cardiovascular disease. Circulation Research. 2017; 121(6):695-710. [DOI:10.1161/CIRCRESAHA.117.311849] [PMID]
  20. Brandão JM, dos Santos Fernandes C, Barroso SG, de Souza Rocha G. [Association of fiber intake and cardiovascular risk in elderly patients (Portuguese)]. International Journal of Cardiovascular Sciences. 2015; 28(6):464-71. https://pesquisa.bvsalud.org/portal/resource/pt/lil-788764
  21. Babiker R, Elmusharaf Kh, Keogh MB, Saeed AM. Effect of Gum Arabic (Acacia Senegal) supplementation on Visceral Adiposity index (VAI) and blood pressure in patients with type 2 diabetes mellitus as indicators of Cardiovascular Disease (CVD): A randomized and placebo-controlled clinical trial. Lipids in Health and Disease. 2018; 17:56. [DOI:10.1186/s12944-018-0711-y] [PMID] [PMCID]
  22. König M, Drewelies J, Norman K, Spira D, Buchmann N, Hülür G, et al. Historical trends in modifiable indicators of cardiovascular health and self-rated health among older adults: Cohort differences over 20 years between the Berlin Aging Study (BASE) and the Berlin Aging Study II (BASE-II). PloS One. 2018; 13(1):e0191699. [DOI:10.1371/journal.pone.0191699] [PMID] [PMCID]
  23. Hosseini SR, Bayani MA, Mohammadi K, Mohammadi E, Bijani A. [Correlation between anthropometric indexes and risk factors of cardiovascular diseases among the elderly population in Amirkola (Persian)]. Feyz. 2017; 21(3):272-9. http://feyz.kaums.ac.ir/article-1-3057-en.html
  24. Ferreira JDF, Moreira RP, Maurício TF, de Lima PA, Cavalcante TF, Costa EC. [Risk factors for cardiovascular disease in the elderly (English-Portuguese). Journal of Nursing UFPE/Revista de Enfermagem UFPE on Line. 2017; 11(12):4895-905. [DOI:10.5205/1981-8963-v11i12a15182p4895-4905-2017]
  25. Grandner MA, Alfonso-Miller P, Fernandez-Mendoza J, Shetty S, Shenoy S, Combs D. Sleep: Important considerations for the prevention of cardiovascular disease. Current Opinion in Cardiology. 2016; 31(5):551-65. [DOI:10.1097/HCO.0000000000000324] [PMID] [PMCID]
  26. Blachier M, Dauvilliers Y, Jaussent I, Helmer C, Ritchie K, Jouven X, et al. Excessive daytime sleepiness and vascular events: The three city study. Annals of Neurology. 2012; 71(5):661-7. [DOI:10.1002/ana.22656] [PMID]
  27. Häusler N, Haba-Rubio J, Heinzer R, Marques-Vidal P. Association of napping with incident cardiovascular events in a prospective cohort study. Heart. 2019; 105(23):1793-8. [DOI:10.1136/heartjnl-2019-314999] [PMID]
  28. Maugeri A, Medina-Inojosa JR, Kunzova S, Agodi A, Barchitta M, Sochor O, et al. Sleep duration and excessive daytime sleepiness are associated with obesity independent of diet and physical activity. Nutrients. 2018; 10(9):1219. [DOI:10.3390/nu10091219] [PMID] [PMCID]
  29. Vashum KP, McEvoy MA, Hancock SJ, Islam MR, Peel R, Attia JR, et al. Prevalence of and associations with excessive daytime sleepiness in an Australian older population. Asia Pacific Journal of Public Health. 2015; 27(2):NP2275-84. [DOI:10.1177/1010539513497783] [PMID]
  30. Samara AM, Sweileh MW, Omari AM, Omari LS, Dagash HH, Sweileh WM, et al. An assessment of sleep quality and daytime sleepiness in hemodialysis patients: A cross-sectional study from Palestine. Sleep Science and Practice. 2019; 3:4. [DOI:10.1177/1010539513497783]
  31. Tam W, Ng SS, To KW, Ko FW, Hui DS. The interaction between hypertension and obstructive sleep apnea on subjective daytime sleepiness. Journal of Clinical Hypertension. 2019; 21(3):390-6. [DOI:10.1111/jch.13485] [PMID]
  32. de Oliveira Diniz DL, Barreto PR, de Bruin PFC, de Bruin VMS. Wake-up stroke: Clinical characteristics, sedentary lifestyle, and daytime sleepiness. Revista da Associação Médica Brasileira. 2016; 62(7):628-34. [DOI:10.1590/1806-9282.62.07.628] [PMID]
  33. Ghaffari F, Zeighami Mohammadi Sh. [Frequency of daytime sleepiness in hypertensive women (Persian)]. Avicenna Journal of Nursing and Midwifery Care. 2011; 19(1):5-15. http://nmj.umsha.ac.ir/article-1-1085-en.html
  34. Foroughan M, Habibi Ghahfarrokhi S, Malakouti S K. [Daytime sleepiness: A factor correlated with mental health of older people (Persian)]. Salmand: Iranian Journal of Ageing. 2012; 7(3):12-20. http://salmandj.uswr.ac.ir/article-1-517-fa.html
  35. Johns MW. A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep. 1991; 14(6):540-5. [DOI:10.1093/sleep/14.6.540] [PMID]
  36. Sadeghniiat Haghighi Kh, Montazeri A, Khajeh Mehrizi A, Aminian O, Rahimi Golkhandan A, Saraei M, et al. The Epworth sleepiness scale: Translation and validation study of the Iranian version. Sleep and Breathing. 2013; 17(1):419-26. [DOI:10.1007/s11325-012-0646-x] [PMID]
  37. Chervin RD, Aldrich MS, Pickett R, Guilleminault G. Comparison of the results of the Epworth sleepiness scale and the multiple sleep latency test. Journal of Psychosomatic Research. 1997; 42(2):145-55. [DOI:10.1016/S0022-3999(96)00239-5]
  38. World Health Organization. Obesity: Preventing and managing the global epidemic: Report of a WHO consultation [Internet]. 2000 [Updated 2000]. Available from: https://apps.who.int/iris/handle/10665/42330
  39. World Health Organization. Waist circumference and waist-hip ratio: Report of a WHO expert consultation, Geneva, 8-11 December 2008 [Internet]. 2011 [Updated 2011]. Available from: https://apps.who.int/iris/handle/10665/44583
  40. Kumar NV, Ismail MH, P M, M G, Tripathy M. Neck circumference and cardio- metabolic syndrome. Journal of Clinical and Diagnostic Research. 2014; 8(7):MC23-5. [DOI:10.7860/JCDR/2014/8455.4641] [PMID] [PMCID]
  41. World Health Organization. Hypertension [Internet]. 2021 [Updated 2021 August 25]. Availble from: https://www.who.int/news-room/fact-sheets/detail/hypertension
  42. Adel Bakir M, Hammad Kh, Bagdadi Kh. Prevalence of metabolic syndrome and its components among type 2 diabetic mellitus Syrian patients according to NCEP-ATP III and IDF diagnostic criteria. Anthropological Review. 2019; 82(1):1-14. [DOI:10.2478/anre-2019-0001]
  43. Lepor NE, Vogel RE; National Cholesterol Education Program Adult Treatment Panel III. Summary of the third report of the National Cholesterol Education Program Adult Treatment Panel III. Reviews in Cardiovascular Medicine. 2001; 2(3):160-5. [PMID]
  44. Foley DJ, Vitiello MV, Bliwise DL, Ancoli-Israel S, Monjan AA, Walsh JK. Frequent napping is associated with excessive daytime sleepiness, depression, pain, and nocturia in older adults: Findings from the National Sleep Foundation ‘2003 sleep in America’ poll. The American Journal of Geriatric Psychiatry. 2007; 15(4):344-50. [DOI:10.1097/01.JGP.0000249385.50101.67] [PMID]
  45. Widiger TA. Diagnostic and statistical manual of mental disorders. In: Kazdin AE, editor. Encyclopedia of Psychology. Vol. 3. Washington, DC: American Psychological Association; 2000. pp. 32-35. [DOI:10.1037/10518-009]
  46. Prinz PN, Vitiello MV, Raskind MA, Thorpy MJ. Geriatrics: Sleep disorders and aging. The New England Journal of Medicine. 1990; 323(8):520-6. [DOI:10.1056/NEJM199008233230805] [PMID]
  47. van der Spuy I, Karunanayake CP, Dosman JA, McMullin K, Zhao G, Abonyi S, et al. Determinants of excessive daytime sleepiness in two First Nation communities. BMC Pulmonary Medicine. 2017; 17:192. [DOI:10.1186/s12890-017-0536-x] [PMID] [PMCID]
  48. Endeshaw Y, Rice TB, Schwartz AV, Stone KL, Manini TM, Satterfield S, et al. Snoring, daytime sleepiness, and incident cardiovascular disease in the health, aging, and body composition study. Sleep. 2013; 36(11):1737-45. [DOI:10.5665/sleep.3140] [PMID] [PMCID]
  49. Empana JP, Dauvilliers Y, Dartigues JF, Ritchie K, Gariepy J, Jouven X, et al. Excessive daytime sleepiness is an independent risk indicator for cardiovascular mortality in community-dwelling elderly: The three city study. Stroke. 2009; 40(4):1219-24. [DOI:10.1161/STROKEAHA.108.530824] [PMID]
  50. Vgontzas AN, Bixler EO, Tan TL, Kantner D, Martin LF, Kales A. Obesity without sleep apnea is associated with daytime sleepiness. Archives of Internal Medicine. 1998; 158(12):1333-7. [DOI:10.1001/archinte.158.12.1333] [PMID]
  51. Punjabi NM, O'hearn DJ, Neubauer DN, Nieto FJ, Schwartz AR, Smith PL, et al. Modeling hypersomnolence in sleep-disordered breathing: A novel approach using survival analysis. American Journal of Respiratory and Critical Care Medicine. 1999; 159(6):1703-9. [DOI:10.1164/ajrccm.159.6.9808095] [PMID]
  52. Panossian LA, Veasey SC. Daytime sleepiness in obesity: Mechanisms beyond obstructive sleep apnea-a review. Sleep. 2012; 35(5):605-15. [DOI:10.5665/sleep.1812] [PMID] [PMCID]
  53. Strand LB, Carnethon M, Biggs ML, Djoussé L, Kaplan RC, Siscovick DS, et al. Sleep disturbances and glucose metabolism in older adults: The cardiovascular health study. Diabetes Care. 2015; 38(11):2050-8. [DOI:10.2337/dc15-0137] [PMID] [PMCID]
  54. Punjabi NM, Haponik E. Ask about daytime sleepiness! Journal of The American Geriatrics Society. 2000; 48(2):228-9. [DOI:10.1111/j.1532-5415.2000.tb03918.x] [PMID]
  55. Chasens ER, Sereika SM, Burke LE. Daytime sleepiness and functional outcomes in older adults with diabetes. The Diabetes Educator. 2009; 35(3):455-64. [DOI:10.1177/0145721709333857] [PMID]
  56. Underner M, Paquereau J, Meurice JC. [Cigarette smoking and sleep disturbance (French)]. Revue des Maladies Respiratoires. 2006; 23(3 Suppl 1):67-77. [DOI:10.1016/S0761-8425(06)71589-3] [PMID]
  57. Gama RL, Távora DG, Bomfim RC, Silva CE, de Bruin VM, de Bruin PFC. Sleep disturbances and brain MRI morphometry in Parkinson’s disease, multiple system atrophy and progressive supranuclear palsy - a comparative study. Parkinsonism & Related Disorders. 2010; 16(4):275-9. [DOI:10.1016/j.parkreldis.2010.01.002] [PMID]
  58. Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, Lin HM, et al. Sleep apnea and daytime sleepiness and fatigue: Relation to visceral obesity, insulin resistance, and hypercytokinemia. The Journal of Clinical Endocrinology and Metabolism. 2000; 85(3):1151-8. [DOI:10.1210/jcem.85.3.6484] [PMID]
  59. Johns MW. Daytime sleepiness, snoring, and obstructive sleep apnea. Chest. 1993; 103(1):30-6. [DOI:10.1378/chest.103.1.30] [PMID]
  60. Ng WL, Orellana L, Shaw JE, Wong E, Peeters A. The relationship between weight change and daytime sleepiness: The sleep heart health study. Sleep Medicine. 2017; 36:109-18. [DOI:10.1016/j.sleep.2017.05.004] [PMID]
Type of Study: Research | Subject: gerontology
Received: 2018/12/31 | Accepted: 2020/07/23 | Published: 2021/10/01

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