Volume 13, Issue 1 (4-2018)                   Salmand: Iranian Journal of Ageing 2018, 13(1): 16-27 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Behjati Ardakani A, Qassemian A, Koushki M, Shakour E, Mehrez A. The Effect of a Resistance Training Course on Blood Pressure and Nitric Oxide Levels in Elderly Women. Salmand: Iranian Journal of Ageing 2018; 13 (1) :16-27
URL: http://salmandj.uswr.ac.ir/article-1-1166-en.html
1- Department of Sport Sciences, Faculty of Literature and Humanities, Shahrekord University, shahrekord, Iran.
2- Department of Physical Education, School of Education & Psychology, Shiraz University, Shiraz, Iran. , ahmadqassemian@gmail.com
3- Department of Physical Education, School of Education & Psychology, Shiraz University, Shiraz, Iran.
Abstract:   (9682 Views)

Objectives Endothelial function is an important factor in the assessment of atherosclerosis, lipid deposition in the inner walls of the arteries, high blood pressure, and heart failure. Vascular endothelial cells play an important role in regulating vascular activities by producing substances such as nitric oxide to stimulate vessels.
Methods & Materials The current study was attempted to find out the effect of resistance training on old women’s plasma nitric oxide levels and blood pressure. Twenty-four postmenopausal women (age: 67.37±6.02, BMI=26.87±4.16, and WHR=0.92±0.4 mean±SD) were selected objectively and divided into control (n=12) and experimental (n=12) groups randomly. Experimental group performed resistance training for eight weeks, three sessions per week with 40-65% intensity. Study variables were measured and recorded before and after training program. Paired and independent sample t tests were used for data analysis. The significance level was lower than 0.05.
Results  The results revealed that resistance training had a significant effect on nitric oxide levels (P=0.01) and blood pressure (P=0.006, P=0.002) in old women. 
Conclusion A period of resistance training with present study characteristics can reduce both systolic and diastolic hypotension and increase plasma nitric oxide levels, and therefore is recommended for prevention of cardiovascular diseases, atherosclerosis, and hypertension in old women.

Full-Text [PDF 2453 kb]   (4367 Downloads) |   |   Full-Text (HTML)  (8951 Views)  
Type of Study: Research | Subject: Clinical
Received: 2017/08/23 | Accepted: 2018/01/21 | Published: 2018/04/01

References
1. Turk JR, Laughlin MH. Physical activity and atherosclerosis: which animal model? Canadian Journal of Applied Physiology. 2004; 29(5):657–83. doi: 10.1139/h04-042 [DOI:10.1139/h04-042]
2. Lakatta EG, Levy D. Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises: Part I: Aging arteries: A "set up" for vascular disease. Circulation. 2003; 107(1):139–46. doi: 10.1161/01.cir.0000048892.83521.58 [DOI:10.1161/01.CIR.0000048892.83521.58]
3. Hagobian TA, Jacobs KA, Subudhi AW, Fattor JA, Rock PB, Muza SR, et al. Cytokine responses at high altitude: Effects of exercise and antioxidants at 4300 m. Medicine & Science in Sports & Exercise. 38(2):276-85. doi: 10.1249/01.mss.0000188577.63910.51 [DOI:10.1249/01.mss.0000188577.63910.51]
4. Kanaley JA, Sames C, Swisher L, Swick AG, Ploutz-Snyder LL, Steppan CM, et al. Abdominal fat distribution in pre- and postmenopausal women: The impact of physical activity, age, and menopausal status. Metabolism. 2001; 50(8):976–82. doi: 10.1053/meta.2001.24931 [DOI:10.1053/meta.2001.24931]
5. Marques E, Carvalho J, Soares JMC, Marques F, Mota J. Effects of resistance and multicomponent exercise on lipid profiles of older women. Maturitas. 2009; 63(1):84–8. doi: 10.1016/j.maturitas.2009.03.003 [DOI:10.1016/j.maturitas.2009.03.003]
6. Sharman MJ, Volek JS. Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men. Clinical Science. 2004; 107(4):365–9. doi: 10.1042/cs20040111 [DOI:10.1042/CS20040111]
7. Moncada S, Palmer RM, Higgs EA. Nitric oxide: Physiology, pathophysiology, and pharmacology. Pharmacological Reviews, 1991; 43(2):109-42. PMID: 1852778 [PMID]
8. Wang JS. Effects of exercise training and detraining on cutaneous microvascular function in man: The regulatory role of endothelium-dependent dilation in skin vasculature. European Journal of Applied Physiology. 2004; 93(4):429–34. doi: 10.1007/s00421-004-1176-4 [DOI:10.1007/s00421-004-1176-4]
9. Fuchsjager-Mayrl G, Pleiner J, Wiesinger GF, Sieder AE, Quittan M, Nuhr MJ, et al. Exercise training improves vascular endothelial function in patients with type 1 diabetes. Diabetes Care. 2002; 25(10):1795–801. doi: 10.2337/diacare.25.10.1795 [DOI:10.2337/diacare.25.10.1795]
10. Davis PG, Bartoli WP, Durstine JL. Effects of acute exercise intensity on plasma lipids and apolipoproteins in trained runners. Journal of Applied Physi-ology. 1992; 72(3):914–9. doi: 10.1152/jappl.1992.72.3.914 [DOI:10.1152/jappl.1992.72.3.914]
11. Koivisto VA, Eriksson J, Taimela S. Exercise and the metabolic syndrome. Diabetologia. 1997; 40(2):125–35. doi: 10.1007/s001250050653 [DOI:10.1007/s001250050653]
12. Poehlman ET, Dvorak RV, DeNino WF, Brochu M, Ades PA. Effects of resistance training and endurance training on insulin sensitivity in nonobese, young women: A controlled randomized trial. Journal of Clinical Endocrinology & Metabolism. 2000; 85(7):2463–8. doi: 10.1210/jcem.85.7.6692 [DOI:10.1210/jcem.85.7.6692]
13. Miyauchi T, Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annual Review of Physiology. 1999; 61(1):391–415. doi: 10.1146/annurev.physiol.61.1.391 [DOI:10.1146/annurev.physiol.61.1.391]
14. Donato A, Lesniewski L, Delp M. The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles. Car-diovascular Research. 2005; 66(2):393–401. doi: 10.1016/j.cardiores.2004.10.023 [DOI:10.1016/j.cardiores.2004.10.023]
15. Wennmalm A, Benthin G, Edlund A, Kieler-Jenson N, Lundin S, Petersson AS, et al. Nitric Oxide Synthesis and Metabolism in Man. Annals of the New York Academy of Sciences. 1994; 714(1):158–64. doi: 10.1111/j.1749-6632.1994.tb12040.x [DOI:10.1111/j.1749-6632.1994.tb12040.x]
16. Rubanyi GM, Vanhoutte PM. Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle. American Journal of Physiology-Heart and Circulatory Physiology. 1986; 250(5):H815–H821. doi: 10.1152/ajpheart.1986.250.5.h815 [DOI:10.1152/ajpheart.1986.250.5.H815]
17. Ku DD, Zaleski JK, Liu S, Brock TA. Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries. American Journal of Physiology-Heart and Circulatory Physiology. 1993; 265(2):H586–H592. doi: 10.1152/ajpheart.1993.265.2.h58
18. Horowitz JR, Rivard A, van der Zee R, Hariawala M, Sheriff DD, Esakof DD, et al. Vascular endothelial growth factor vascular permeability factor pro-duces nitric oxide-dependent hypotension-evidence for a maintenance role in quiescent adult endothelium. Arteriosclerosis, Thrombosis, and Vascular Biol-ogy. 1997; 17(11):2793–800. doi: 10.1161/01.atv.17.11.2793 [DOI:10.1161/01.ATV.17.11.2793]
19. Chou TC, Yen MH, Li CY, Ding YA. Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension. 1998; 31(2):643–8. doi: 10.1161/01.hyp.31.2.643 [DOI:10.1161/01.HYP.31.2.643]
20. Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, et al. Age-related reduction of NO availability and oxidative stress in humans. Hy-pertension. 2001; 38(2):274–9. doi: 10.1161/01.hyp.38.2.274 [DOI:10.1161/01.HYP.38.2.274]
21. Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circulation Research. 2001; 88(8):756–62. doi: 10.1161/hh0801.089861 [DOI:10.1161/hh0801.089861]
22. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. Journal of Clinical Investigation. 1989; 83(5):1774–7. doi: 10.1172/jci114081 [DOI:10.1172/JCI114081]
23. Danilov AI, Andersson M, Bavand N, Wiklund NP, Olsson T, Brundin L. Nitric oxide metabolite determinations reveal continuous inflammation in mul-tiple sclerosis. Journal of Neuroimmunology. 2003; 136(1-2):112–8. doi: 10.1016/s0165-5728(02)00464-2 [DOI:10.1016/S0165-5728(02)00464-2]
24. Kahl KG, Zielasek J, Uttenthal LO, Rodrigo J, Toyka KV, Schmidt HHHW. Protective role of the cytokine-inducible isoform of nitric oxide synthase induc-tion and nitrosative stress in experimental autoimmune encephalomyelitis of the DA rat. Journal of Neuroscience Research. 2003; 73(2):198–205. doi: 10.1002/jnr.10649 [DOI:10.1002/jnr.10649]
25. Yang AL, Tsai SJ, Jiang MJ, Jen CJ, Chen H. Chronic exercise increases both inducible and endothelial nitric oxide synthase gene expression in endothelial cells of rat aorta. Journal of Biomedical Science. 2002; 9(2):149–55. doi: 10.1007/bf02256026 [DOI:10.1007/BF02256026]
26. Kingwell BA. Nitric oxide-mediated metabolic regulation during exercise: effects of training in health and cardiovascular disease. The FASEB Journal. 2000; 14(12):1685–96. doi: 10.1096/fj.99-0896rev [DOI:10.1096/fj.99-0896rev]
27. Zaros PR, Pires CER, Bacci M, Moraes C, Zanesco A. Effect of 6-months of physical exercise on the nitrate/nitrite levels in hypertensive postmenopausal women. BMC Women's Health. 2009; 9(1). doi: 10.1186/1472-6874-9-17 [DOI:10.1186/1472-6874-9-17]
28. Engelke KA, Halliwill JR, Proctor DN, Dietz NM, Joyner MJ. Contribution of nitric oxide and prostaglandins to reactive hyperemia in the human forearm. Journal of Applied Physiology. 1996; 81(4):1807–14. doi: 10.1152/jappl.1996.81.4.1807 [DOI:10.1152/jappl.1996.81.4.1807]
29. Joyner MJ, Dietz NM. Nitric oxide and vasodilation in human limbs. Journal of Applied Physiology. 1997; 83(6):1785–96. doi: 10.1152/jappl.1997.83.6.1785 [DOI:10.1152/jappl.1997.83.6.1785]
30. Jungersten L, Ambring A, Wall B, Wennmalm Å. Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. Journal of Applied Physiology. 1997; 82(3):760–4. doi: 10.1152/jappl.1997.82.3.760 [DOI:10.1152/jappl.1997.82.3.760]
31. Guzel NA, Hazar S, Erbas D. Effects of different resistance exercise protocols on nitric oxide, lipid peroxidation and creatine kinase activity in sedentary males. Journal of Sports Science & Medicine. 2007; 6(4):417-22. PMCID: PMC3794479 [PMID] [PMCID]
32. Harris MB, Mitchell BM, Sood SG, Webb RC, Venema RC. Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise. European Journal of Applied Physiology. 2008; 104(5):795–802. doi: 10.1007/s00421-008-0833-4 [DOI:10.1007/s00421-008-0833-4]
33. Song W, Kwak HB, Kim JH, Lawler JM. Exercise training modulates the nitric oxide synthase profile in skeletal muscle from old rats. The Journals of Ger-ontology Series A: Biological Sciences and Medical Sciences. 2009; 64(5):540-49. doi: 10.1093/gerona/glp021 [DOI:10.1093/gerona/glp021]
34. Gielen S, Adams V, Mobius-Winkler S, Linke A, Erbs S, Yu J, et al. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. Journal of the American College of Cardiology. 2003; 42(5):861-68. doi: 10.1016/s0735-1097(03)00848-9 [DOI:10.1016/S0735-1097(03)00848-9]
35. Mcallister RM, Hirai T, Musch TI. ontribution of Endothelium-Derived Nitric Oxide (EDNO) to the skeletal muscle blood flow response to exercise. Medi-cine & Science in Sports & Exercise. 1995; 27(8):1145-51. doi: 10.1249/00005768-199508000-00007 [DOI:10.1249/00005768-199508000-00007]
36. Arsenault BJ, Côté M, Cartier A, Lemieux I, Després JP, Ross R, et al. Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure. Atherosclerosis. 2009; 207(2):530–3. doi: 10.1016/j.atherosclerosis.2009.05.009 [DOI:10.1016/j.atherosclerosis.2009.05.009]
37. Delp MD, McAllister RM, Laughlin MH. Exercise training alters endothelium-dependent vasoreactivity of rat abdominal aorta. Journal of Applied Physi-ology. 1993; 75(3):1354–63. doi: 10.1152/jappl.1993.75.3.1354 [DOI:10.1152/jappl.1993.75.3.1354]
38. Green DJ, Cable NT, Fox C, Rankin JM, Taylor RR. Modification of forearm resistance vessels by exercise training in young men. Journal of Applied Physi-ology. 1994; 77(4):1829–33. doi: 10.1152/jappl.1994.77.4.1829 [DOI:10.1152/jappl.1994.77.4.1829]
39. Jungersten L, Ambring A, Wall B, Wennmalm Å. Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. Journal of Applied Physiology. 1997; 82(3):760–4. doi: 10.1152/jappl.1997.82.3.760 [DOI:10.1152/jappl.1997.82.3.760]
40. Duncker D. Nitric oxide contributes to the regulation of vasomotor tone but does not modulate O2-consumption in exercising swine. Cardiovascular Re-search. 2000; 47(4):738–48. doi: 10.1016/s0008-6363(00)00143-7 [DOI:10.1016/S0008-6363(00)00143-7]
41. Johansen KL. Exercise and chronic kidney disease: current recommendations. Sports Medicine. 2005; 35(6):485–99. doi: 10.2165/00007256-200535060-00003 [DOI:10.2165/00007256-200535060-00003]
42. Hinkle JL, Cheever KH. Brunner and Suddarth's textbook of medical-surgical nursing [P. Sami, Persian Trans]. Tehran: Boshra; 2000.
43. Yang K, Bernardo LM, Sereika SM, Conroy MB, Balk J, Burke LE. Utilization of 3-month Yoga program for Adults at High Risk for Type 2 Diabetes. Evi-dence-Based Complementary and Alternative Medicine. 2011; 2011:1–6. doi: 10.1093/ecam/nep117 [DOI:10.1093/ecam/nep117]
44. Innes KE, Vincent HK. The influence if yoga-based programs on risk profiles in adults with type 2 diabetes mellitus: A systsmatic review. Evidence-Based Complementary and Alternative Medicine. 2007; 4(4):469–86. doi: 10.1093/ecam/nel103 [DOI:10.1093/ecam/nel103]
45. Miller BW, Cress CL, Johnson ME, Nichols DH, Schnitzler MA. Exercise during hemodialysis decreases the use of antihypertensive medications. American Journal of Kidney Diseases. 2002; 39(4):828–33. doi: 10.1053/ajkd.2002.32004 [DOI:10.1053/ajkd.2002.32004]
46. Hordern MD, Cooney LM, Beller EM, Prins JB, Marwick TH, Coombes JS. Determinants of changes in blood glucose response to short-term exercise training in patients with Type 2 diabetes. Clinical Science. 2008; 115(9):273–81. doi: 10.1042/cs20070422 [DOI:10.1042/CS20070422]
47. Chen HH. Effects of one-year swimming training on blood pressure and insulin sensitivity in mild hypertensive young patients. The Chinese Journal of Physiology. 2010; 53(4):185-9. doi: 10.4077/cjp.2010.amk042 [DOI:10.4077/CJP.2010.AMK042]
48. Andreazzi AE, Scomparin DX, Mesquita FP, Balbo SL, Gravena C, De Oliveira JC, et al. Swimming exercise at weaning improves glycemic control and inhibits the onset of monosodium L-glutamate-obesity in mice. Journal of Endocrinology. 2009; 201(3):351–9. doi: 10.1677/joe-08-0312 [DOI:10.1677/JOE-08-0312]
49. Johansen KL. Exercise and chronic kidney disease: Current recommendations. Sports Medicine. 2005; 35(6):485–99. doi: 10.2165/00007256-200535060-00003 [DOI:10.2165/00007256-200535060-00003]

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Iranian Journal of Ageing

Designed & Developed by : Yektaweb