Volume 13, Issue 4 (Winter 2019)                   Salmand: Iranian Journal of Ageing 2019, 13(4): 428-439 | Back to browse issues page

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Valipour Dehnou V, Motamedi R. The Effect of One Circuit Training Session on the Serum Levels of Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor-1 in the Elderly. Salmand: Iranian Journal of Ageing 2019; 13 (4) :428-439
URL: http://salmandj.uswr.ac.ir/article-1-1315-en.html
The Effect of One Circuit Training Session on the Serum Levels of Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor-1 in the Elderly
Vahid Valipour Dehnou * 1, Reza Motamedi2
1- Department of Sports Sciences, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran. , valipour.v@lu.ac.ir
2- Borujerd Islamic Azad Uni.
Abstract:   (5576 Views)

Objectives Physical activity is effective in improving cognitive function in older adults. Such function may be mediated by the upregulation of neurotrophic growth factors like Brain-Derived Neurotrophic Factor (BDNF) and Insulin-like Growth Factor-1 (IGF-1). The present study aimed to assess and compare the effect of 1 session of circuit training on the serum levels of BDNF and IGF-1 in elderly males and females.
Methods & Materials This quasi-experimental study was carried out in Khorramabad City, Iran in 2017. Five men (Mean±SD age=64.40±6.69 years, Mean±SD weight=74.8±5.63 kg, Mean±SD height=174.4±4.16 cm), and 5 women (Mean±SD age=64.5±60.55 years, Mean±SD weight=65±5.43 kg, Mean±SD height=167±5.Micipated voluntarily in this study. Three days before performing the training protocol, all subjects became familiarized with the methods of performing exercises at their homes. On the training day, at first, their blood samples were obtained; then, the subjects performed circuit training for approximately 1 hour. Second blood samples were obtained 3 minutes after the training session. The Paired sample t test and analysis of covariance were used to identify any significant differences. The statistical significance level was set at P<0.05.
Results This study was carried out on 10 elderly males and females. Results suggested that the serum concentration of BDNF (P<0.05) significantly increased and IGF-1 (P<0.05) significantly decreased. However, the differences between males and females in BDNF (P>0.05) and IGF-1 (P>0.05) were not significant. However, the percent changes of BDNF (22.78 vs. 27.91) and IGF-1 (-10.55 vs. -12.37) were lower in males than females.
Conclusion Circuit training for approximately 1 hour increases the serum concentration of BDNF and decreases IGF-1 in elderly males and females. Therefore, it is recommended that a body weight circuit training be performed in elderly males and females to improve their cognitive status.

Keywords: Sex, Elderly, Cognition, BDNF, IGF-1
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Type of Study: Research | Subject: gerontology
Received: 2018/05/23 | Accepted: 2018/11/10 | Published: 2019/01/01
References
1. Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, et al. A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biology. 2015; 16(185):1-17. [DOI:10.1186/s13059-015-0750-x]
2. Kirk Sanchez NJ, McGough EL. Physical exercise and cognitive performance in the elderly: Current perspectives. Clinical Interventions in Aging. 2014; 9:51–62. [DOI:10.2147/CIA.S39506] [PMID] [PMCID] [DOI:10.2147/CIA.S39506]
3. Proia P, Di Liegro CM, Schiera G, Fricano A, Di Liegro I. Lactate as a metabolite and a regulator in the central nervous system. International Journal of Molecular Sciences. 2016; 17(1450):1-20. [DOI:10.3390/ijms17091450] [DOI:10.3390/ijms17091450]
4. Duzel E, van Praag H, Sendtner M. Can physical exercise in old age improve memory and hippocampal function? Brain. 2016; 139(3):662-73. [DOI:10.1093/brain/awv407] [DOI:10.1093/brain/awv407]
5. Seene T, Kaasik P. Age-associated changes in skeletal muscle regeneration: Effect of exercise. Advances in Aging Research. 2015; 4:230-41. [DOI:10.4236/aar.2015.46025]
6. Boecker H, Hillman CH, Scheef L, Strüder HK. Functional neuroimaging in exercise and sport sciences. Berlin: Springer; 2012. [DOI:10.1007/978-1-4614-3293-7]
7. Coelhoa FGM, Vitala TM, Steina AM, Arantesa FJ, Ruedac AV, Camarinic R, et al. Acute aerobic exercise increases brain-derived neurotrophic factor levels in elderly with Alzheimer's disease. Journal of Alzheimer's Disease. 2014; 39(2):401–8. [DOI:10.3233/JAD-131073] [DOI:10.3233/JAD-131073]
8. Lista I, Sorrentino G. Biological mechanisms of physical activity in preventing cognitive decline. Cellular and Molecular Neurobiology. 2010; 30(4):493-503. [DOI:10.1007/s10571-009-9488-x] [PMID] [DOI:10.1007/s10571-009-9488-x]
9. Walsh JJ, Scribbans TD, Bentley RF, Kellawan JM, Gurd B, Tschakovsky ME. Neurotrophic growth factor responses to lower body resistance training in older adults. Applied Physiology, Nutrition, and Metabolism. 2016; 41(3):315-23. [DOI:10.1139/apnm-2015-0410] [PMID]
10. Zoladz JA, Pilc A, Majerczak J, Grandys M, Zapart bukowska J, Duda K. Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men. Journal of Physiology and Pharmacology. 2008; 59(7):119-32. [PMID] [PMID]
11. Swift DL, Johannsen NM, Myers VH, Earnest CP, Smits JAJ, Blair SN, et al. The effect of exercise training modality on serum brain derived neurotrophic factor levels in individuals with type 2 diabetes. PLOS One. 2012; 7(8):1-7. [doi:10.1371/journal.pone.0042785] [DOI:10.1371/journal.pone.0042785]
12. Gomez Pinilla F, Vaynman S, Ying Z. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. European Journal of Neuroscience. 2008; 28(11):2278-87. [DOI:10.1111/j.1460-9568.2008.06524.x] [PMID] [PMCID] [DOI:10.1111/j.1460-9568.2008.06524.x]
13. Åberg ND, Brywe KG, Isgaard J. Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. The Scientific World Journal. 2006; 6:53-80. [DOI:10.1100/tsw.2006.22] [DOI:10.1100/tsw.2006.22]
14. Smolarek AC, Ferreira LHB, Mascarenhas LPG, McAnulty SR, Varela KD, Dangui MC, et al. The effects of strength training on cognitive performance in elderly women. Clinical Interventions in Aging. 2016; 11:749-54. [doi:10.2147/CIA.S102126] [DOI:10.2147/CIA.S102126]
15. Silverman MN, Deuster PA. Biological mechanisms underlying the role of physical fitness in health and resilience. Interface Focus. 2014; 4(5):1-12. [DOI: 10.1098/rsfs.2014.0040] [PMID] [PMCID] [DOI:10.1098/rsfs.2014.0040]
16. Voss MW, Weng TB, Burzynska AZ, Wong CN, Cooke GE, Clark R, et al. Fitness, but not physical activity, is related to functional integrity of brain networks associated with aging. NeuroImage. 2016; 131:113–25. [DOI:10.1016/j.neuroimage.2015.10.044] [PMID] [PMCID] [DOI:10.1016/j.neuroimage.2015.10.044]
17. Forti LN, Roie EV, Njemini R, Coudyzer W, Beyer I, Delecluse C, et al. Dose-and gender-specific effects of resistance training on circulating levels of Brain Derived Neurotrophic Factor (BDNF) in community-dwelling older adults. Experimental Gerontology. 2015; 70:144-9. [DOI:10.1016/j.exger.2015.08.004] [PMID] [DOI:10.1016/j.exger.2015.08.004]
18. Forti LN, Njemini R, Beyer I, Eelbode E, Meeusen R, Mets T, et al. Strength training reduces circulating interleukin-6 but not brain-derived neurotrophic factor in community-dwelling elderly individuals. Age (Dordr). 2014; 36(5):9704. [DOI:10.1007/s11357-014-9704-6] [PMID] [PMCID] [DOI:10.1007/s11357-014-9704-6]
19. Kanoski SE, Davidson TL. Western Diet Consumption and Cognitive Impairment: Links to Hippocampal Dysfunction and Obesity. Physiology & Behavior. 2011; 103(1):59-68. [DOI: 10.1016/j.physbeh.2010.12.003] [PMID] [PMCID] [DOI:10.1016/j.physbeh.2010.12.003]
20. Proctor DN, Balagopal P, Nair KS. Age-related Sarcopenia in humans is associated with reduced synthetic rates of specific muscle proteins. Journal of Nutrition. 1998; 128(Suppl.2):351–55. [DOI:10.1093/jn/128.2.351S] [PMID] [DOI:10.1093/jn/128.2.351S]
21. Nikolic M, Bajek S, Bobinac D, Vranic TS, Jerkovic R. Aging of human skeletal muscles. Collegium Antropologicum. 2005; 29(1):67–70. [PMID] [PMID]
22. Arnarson A, Gudny Geirsdottir O, Ramel A, Jonsson PV, Thorsdottir I. Insulin-like growth factor-1 and resistance exercise in community dwelling old adults. The Journal of Nutrition, Health and Aging. 2015; 19(8):856-60. [DOI:10.1007/s12603-015-0547-3] [PMID]
23. Farooqui T, Farooqui AA. Diet and exercise in cognitive function and neurological diseases. Hoboken: Wiley‐Blackwell; 2015. [DOI:10.1002/9781118840634]
24. Cotman CW, Berchtold NC. Exercise: A behavioral intervention to enhance brain health and plasticity. Trends in Neurosciences. 2002; 25(6):295-301. [PMID] [DOI:10.1016/S0166-2236(02)02143-4]
25. Hillman CH, Erickson KI, Kramer AF. Be smart, exercise your heart: exercise effects on brain and cognition. Nature Reviews, Neuroscience. 2008; 9(1):58-65. [DOI:10.1038/nrn2298] [PMID] [DOI:10.1038/nrn2298]
26. Maass A, Düzel S, Brigadski T, Goerke M, Becke A, Sobieray U, et al. Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults. NeuroImage. 2016; 131:142-54. [DOI:10.1016/j.neuroimage.2015.10.084] [PMID] [DOI:10.1016/j.neuroimage.2015.10.084]
27. Lautenschlager NT, Cox K, Cyarto EV. The influence of exercise on brain aging and dementia. Biochimica et Biophysica Acta. 2012; 1822(3):474-81. [DOI:10.1016/j.bbadis.2011.07.010] [PMID] [DOI:10.1016/j.bbadis.2011.07.010]
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