Volume 13, Issue 3 (10-2018)                   Salmand: Iranian Journal of Ageing 2018, 13(3): 324-333 | Back to browse issues page

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Valipour Dehnouhnou V, Abbasi Moghadam M, Soleymani Farsani M. Effects of Early Morning Exercise on Serum Brain-Derived Neurotrophic Factor Level and Its Relation With Blood Cholesterol and Glucose Levels in the Elderly Men. Salmand: Iranian Journal of Ageing. 2018; 13 (3) :324-333
URL: http://salmandj.uswr.ac.ir/article-1-1355-en.html
1- Department of Sports Sciences, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran. , valipour.v@lu.ac.ir
2- Department of Sports Sciences, Faculty of Literature and Humanities, Lorestan University, Khorramabad, Iran.
Abstract:   (5444 Views)

Objectives Early morning exercise is prevalent in Iranian population, and yet no study has assessed its effect on brain-derived neurotrophic factor. Therefore, the purpose of this study was to assess the effect of early morning exercise on serum levels of brain-derived neurotrophic factor and its relation with cholesterol levels in the elderly males in Khorramabad City, Iran.
Methods & Materials In this quasi-experimental study, 13 older men (mean [SD] age: 56.46[3.93] y; mean [SD] weight 82.46[8.23] kg; mean [SD] height: 175.46[5.17] cm) voluntarily participated. In the training day, at first, blood samples were obtained at 07:30 AM in fasting state. Then, subjects performed training protocol for 50 min duration that included 15 min warm-up, 25 min main activity, and 10 min cool-down, and after three min, subsequent blood samples were obtained. To measure serum levels of glucose, cholesterol, the Brain-Derived Neutrophilic Factor (BDNF) enzymatic and ELISA methods were used, respectively. To analyze the obtained data, paired-samples t test and Pearson correlation were used, and statistical significance was set at P<0.05. 
Results Results showed that serum concentration of BDNF (P=0.002) and glucose (P=0.01) increased significantly. Also, there were no significant correlations between serum concentration of BDNF and glucose in both pretest and posttest (P>0.05). However, there were near significant negative correlation between serum concentration of BDNF and cholesterol in pretest (r=-0.53, P=0.061) and significant negative correlation in posttest (r=-0.703, P=0.007).
Conclusion Early morning exercise for approximately 50 minutes increases serum concentration of BDNF and glucose in elderly males. Also, there is no significant positive correlation between them. But, there is significant negative correlation between serum concentration of BDNF and cholesterol. Therefore, early morning exercise for the elderly men is recommended to improve brain health. Also, older men, if they have normal cholesterol levels, will get more benefits from early morning exercise.

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Type of Study: Applicable | Subject: gerontology
Received: 2018/04/04 | Accepted: 2018/07/28 | Published: 2018/10/01

1. Huang T, Larsen KT, Ried-Larsen M, Møller NC, Andersen LB. The effects of physical activity and exercise on brain-derived neurotrophic factor in healthy humans: A review. Scandinavian Journal of Medicine & Science in Sports. 2014; 24(1):1–10. [DOI:10.1111/sms.12069] [PMID] [DOI:10.1111/sms.12069]
2. Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Ito K, et al. A randomized controlled trial of multicomponent exercise in older adults with mild cognitive impairment. PLoS ONE. 2013; 8(4):e61483. [DOI:10.1371/journal.pone.0061483] [DOI:10.1371/journal.pone.0061483]
3. Chang YK, Alderman BL, Chu CH, Wang CC, Song TF, Chen FT. Acute exercise has a general facilitative effect on cognitive function: A combined ERP temporal dynamics and BDNF study. Psychophysiology. 2016; 54(2):289-300. [DOI:10.1111/psyp.12784] [PMID] [DOI:10.1111/psyp.12784]
4. Veasey RC, Haskell-Ramsay CF, Kennedy DO, Tiplady B, Stevenson EJ. The effect of breakfast prior to morning exercise on cognitive performance, mood and appetite later in the day in habitually active women. Nutrients. 2015; 7(7):5712-32. [DOI:10.3390/nu7075250] [PMID] [PMCID] [DOI:10.3390/nu7075250]
5. Coelhoa FGM, Vitala TM, Steina AM, Arantesa FJ, Ruedac AV, Camarinic R, et al. Acute aerobic exercise increases brain-derived neurotrophic factor levels in elderly with Alzheimer's disease. Journal of Alzheimer's Disease. 2014; 39(2):401–8. [DOI:10.3233/JAD-131073] [PMID] [DOI:10.3233/JAD-131073]
6. Karczewska-Kupczewska M, Kowalska I, Nikolajuk A, Adamska A, Zielinska M, Kaminska N, et al. Circulating brain-derived neurotrophic factor concentration is downregulated by intralipid/heparin infusion or high-fat meal in young healthy male subjects. Diabetes Care. 2012; 35(2):358-62. [DOI:10.2337/dc11-1295] [PMID] [PMCID] [DOI:10.2337/dc11-1295]
7. Farooqui T, Farooqui AA. Diet and exercise in cognitive function and neurological diseases. Hoboken, New Jersey: Wiley-Blackwell; 2015. [DOI:10.1002/9781118840634] [DOI:10.1002/9781118840634]
8. Marosi K, Mattson MP. BDNF mediates adaptive brain and body responses to energetic challenges. Trends Endocrinol Metab. 2014; 25(2):89–98. [DOI:10.1016/j.tem.2013.10.006] [PMID] [PMCID] [DOI:10.1016/j.tem.2013.10.006]
9. Vella CA, Kravitz L, Janot JM. A review of the impact of exercise on cholesterol levels. IDEA Health & Fitness Source. 2001; 19(10):48-54.
10. Mohammadi MM, Esmaeilivand M. [Attitudes toward caring of the elderly from the perspective of nursing and midwifery students in Kermanshah Province in 2015 (Persian)]. Iranian Journal of Ageing. 2017; 11(4):476-83.
11. Benloucif S, Orbeta L, Ortiz R, Janssen I, Finkel SI, Bleiberg J, et al. Morning or evening activity improves neuropsychological performance and subjective sleep quality in older adults. Sleep. 2004; 27(8):1542-51. [DOI:10.1093/sleep/27.8.1542] [PMID] [DOI:10.1093/sleep/27.8.1542]
12. Palomer E, Martin-Segura A, Baliyan S, Ahmed T, Balschun D, Venero C, et al. Aging triggers a repressive chromatin state at BDNF promoters in hippocampal neurons. Cell Reports. 2016; 16(11):2889–900. [DOI:10.1016/j.celrep.2016.08.028] [PMID] [DOI:10.1016/j.celrep.2016.08.028]
13. Perrey S. Promoting motor function by exercising the brain. Brain Sciences. 2013; 3(1):101-22. [DOI:10.3390/brainsci3010101] [PMID] [PMCID] [DOI:10.3390/brainsci3010101]
14. Yarrowa JF, Whitec LJ, McCoya SC, Borst SE. Training augments resistance exercise induced elevation of circulating Brain Derived Neurotrophic Factor (BDNF). Neuroscience Letters. 2010; 479(2):161-5. [DOI:10.1016/j.neulet.2010.05.058] [PMID] [DOI:10.1016/j.neulet.2010.05.058]
15. Robertson T, Palmer R, Doyle A, Griffin B, Hampton S, Collins A. Morning exercise appears to promote greater fat oxidation and reduce postprandial lipaemic response more than evening exercise. Proceedings of the Nutrition Society. 2011. [DOI:10.1017/S0029665111004794] [DOI:10.1017/S0029665111004794]
16. Jung SH, Kim J, Davis JM, Blair SN, Cho HC. Association among basal serum BDNF, cardiorespiratory fitness and cardiovascular disease risk factors in untrained healthy Korean men. European Journal of Applied Physiology. 2011; 111(2):303-11. [DOI:10.1007/s00421-010-1658-5] [PMID] [DOI:10.1007/s00421-010-1658-5]
17. Fukui K, Ferris HA, Kahn CR. Effect of cholesterol reduction on receptor signaling in neurons. Journal of Biological Chemistry. 2015; 290(44):26383-92. [DOI:10.1074/jbc.M115.664367] [PMID] [PMCID] [DOI:10.1074/jbc.M115.664367]
18. Suzuki S, Kiyosue K, Hazama S, Ogura A, Kashihara M, Hara T, et al. Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development. Journal of Neuroscience. 2007; 27(24):6417–27. [DOI:10.1523/JNEUROSCI.0690-07.2007] [PMID] [DOI:10.1523/JNEUROSCI.0690-07.2007]
19. Gonzalez A, Moya-Alvarado G, Gonzalez-Billaut C, Bronfman FC. Cellular and molecular mechanisms regulating neuronal growth by Brain-Derived Neurotrophic Factor. Cytoskeleton. 2016; 73(10):612-28. [DOI:10.1002/cm.21312] [PMID] [DOI:10.1002/cm.21312]
20. Nourshahi M, Hovanloo F, Arbabi A. [Effect of exercise with moderate intensity in the morning on some factors of immune systems in adults (Persian)]. Iranian Journal of Endocrinology & Metabolism. 2008; 10(3):241-5.

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