Volume 16, Issue 2 (Summer 2021)                   Salmand: Iranian Journal of Ageing 2021, 16(2): 234-247 | Back to browse issues page


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Hasanvand B, Farhadi A. Effect of Combined Exercise and Ginkgo Biloba Supplementation for 8 Weeks on Brain-derived Neurotrophic Factor Level in Depressed Older Men. Salmand: Iranian Journal of Ageing. 2021; 16 (2) :234-247
URL: http://salmandj.uswr.ac.ir/article-1-1893-en.html
1- Department of Physical Education, Faculty of Humanities, Khorramabad Branch, Islamic Azad University, Iran. , hasanvand121@gmail.com
2- Department of Physical Education, Faculty of Humanities, Khorramabad Branch, Islamic Azad University, Iran.
Abstract:   (858 Views)
Objectives: The current study aims to examine the effect of combined exercises and ginkgo biloba supplementation for 8 weeks on Brain-Derived Neurotrophic Factor (BDNF) level in depressed older men.
Methods & Materials: Forty depressed older men were randomly divided into four groups of exercise (n=10), supplementation (n=10), exercise + supplementation (n=10), and control (n=10). In the pre-test phase, blood samples were taken from the subjects. Then the participants in the exercise group performed combined exercises for eight weeks, 3 sessions per week. Those in the supplementation group, the subjects were given 80 mg of ginkgo biloba extract daily for eight weeks. In the exercise + supplementation group, the subjects received both interventions simultaneously. Blood samples were taken again 24 hours after the end of intervention. Collected data were analyzed using paired t-test, one-way ANOVA, and Bonferroni Post Hoc Test.
Results: Eight weeks of combined exercise alone, ginkgo biloba supplementation alone, and combined exercise and ginkgo biloba supplementation simultaneously significantly increased BDNF level in depressed older men (P<0.05). The increase in the BDNF level of subjects in the exercise + supplementation group was higher (84.78) compared to the exercise (74.37) and supplementation (72.20) groups.
Conclusion: Simultaneous use of combined exercises and ginkgo biloba supplementation can be used by geriatricians to improve brain function of depressed older men.
Full-Text [PDF 6501 kb]   (312 Downloads)    
Type of Study: Applicable | Subject: gerontology
Received: 2019/09/05 | Accepted: 2020/11/29 | Published: 2021/07/01

References
1. (1) Alipour F, Sajadi H, Forouzan A, Biglarian A, Jalilian A. Quality of life in elderly region 2 Tehran. Iranian journal of ageing. 2008;3(3&4):75-83.
2. (2) Sharifzadeh G, Moodi M, Akhbari H. Investigating health status of older people supported by Imam. Iranian journal of ageing. 2010 Oct 10;5(3):52-60.
3. (3) Kochaki G, Hojjati H, Sanagoo A. The Relationship between Loneliness and Life Satisfaction of the Elderly in Gorgan and Gonbad Cities. Journal of Gorgan Bouyeh Faculty of Nursing & Midwifery. 2012; 9(1): 61-68.
4. (4) Khodadadi N, Sheikholeslami F, Reza Masouleh SH, Yazdani M. Rate of depression in late-life in superannuated government employed center. Guilan University of medical sciences Journal. 2003; 40(4): 335-45.
5. (5) Sajadi H, Mohaqeqi Kamal H, Vameghi M, Forozan AS, Rafei H, Nosratabadi M. Systematic review of prevalence and risk factors associated with depression and its treatment in Iranian elderly. Iranian Journal of Ageing. 2013 Jan 10;7(4):7-15.
6. (6) Lai DW. Impact of culture on depressive symptoms of elderly Chinese immigrants. The Canadian Journal of Psychiatry. 2004 Dec;49(12):820-7. [DOI:10.1177/070674370404901205]
7. (7) Cole MG, Dendukuri N. Risk factors for depression among elderly community subjects: a systematic review and meta-analysis. American journal of psychiatry. 2003 Jun 1;160(6):1147-56. [DOI:10.1176/appi.ajp.160.6.1147]
8. (8) Adlard PA, Cotman CW. Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression. Neuroscience. 2004 Jan 1;124(4):985-92. [DOI:10.1016/j.neuroscience.2003.12.039]
9. (9) Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kambayashi JI, Sun B, Tandon NN. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thrombosis and haemostasis. 2002;87(04):728-34. [DOI:10.1055/s-0037-1613072]
10. (10) Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology. 1998 Dec 1;37(12):1553-61. [DOI:10.1016/S0028-3908(98)00141-5]
11. (11) Ploughman M. Exercise is brain food: the effects of physical activity on cognitive function. Developmental neurorehabilitation. 2008 Jan 1;11(3):236-40. [DOI:10.1080/17518420801997007]
12. (12) Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nature neuroscience. 2003 Jul;6(7):736-42. [DOI:10.1038/nn1073]
13. (13) Tsuchida A, Nonomura T, Nakagawa T, Itakura Y, Ono‐Kishino M, Yamanaka M, Sugaru E, Taiji M, Noguchi H. Brain‐derived neurotrophic factor ameliorates lipid metabolism in diabetic mice. Diabetes, obesity and metabolism. 2002 Jul;4(4):262-9. [DOI:10.1046/j.1463-1326.2002.00206.x]
14. (14) Knaepen K, Goekint M, Heyman EM, Meeusen R. Neuroplasticity-exercise-induced response of peripheral brain-derived neurotrophic factor. Sports medicine. 2010 Sep 1;40(9):765-801. [DOI:10.2165/11534530-000000000-00000]
15. (15) Pilc J. The effect of physical activity on the brain derived neurotrophic factor: from animal to human studies. Journal of physiology and pharmacology. 2010;61(5):533-41.
16. (16) Nofuji YU, Suwa M, Moriyama Y, Nakano H, Ichimiya A, Nishichi R, Sasaki H, Radak Z, Kumagai S. Decreased serum brain-derived neurotrophic factor in trained men. Neuroscience letters. 2008 May 23;437(1):29-32. [DOI:10.1016/j.neulet.2008.03.057]
17. (17) Dubber MJ, Kanfer I. Determination of terpene trilactones in Ginkgo biloba solid oral dosage forms using HPLC with evaporative light scattering detection. Journal of pharmaceutical and biomedical analysis. 2006 Apr 11;41(1):135-40. [DOI:10.1016/j.jpba.2005.11.010]
18. (18) Gardner CD, Taylor-Piliae RE, Kiazand A, Nicholus J, Rigby AJ, Farquhar JW. Effect of Ginkgo biloba (EGb 761) on treadmill walking time among adults with peripheral artery disease: a randomized clinical trial. Journal of cardiopulmonary rehabilitation and prevention. 2008 Jul;28(4):258. [DOI:10.1097/01.HCR.0000327184.51992.b8]
19. (19) Bing Y, Zhaobao W. Effects of Ginkgo biloba extract on free radical metabolism of liver in mice during endurance metabolism. African Journal of Traditional, Complementary and Alternative Medicines. 2010;7(4). [DOI:10.4314/ajtcam.v7i4.56691]
20. (20) Haji Rezaei B, Barari A, Abbasi Daloo A. Ginkgo biloba extract and swimming exercise on brain-derived neurotrophic factor and plasma N / methyl-D-aspartate receptor in untrained girls. Journal of Medicinal Plants. 2015; 14 (2): 191-183.
21. (21) Sharifi GH, Banihashemi M, Rahnama N, Babaimazraeno A. Comparison of the effect of 8 weeks aerobic training and resistance training on the level of brain-derived neurotrophic factor in elderly men. Journal of Elderly Research. 2015; 10 (3): 155-148.
22. (22) Ravasi AS, Poornemati P, Kordi MR, Hedayati M. The effect of two type of resistance and endurance exercise on BDNF and cortisol of young male mice. Harekat. 2013;16(1): 49-78.
23. (23) Mojtahedi S, Shabkhiz F, Akbarnejad A, Salehian O. Effect of 8 weeks Resistance Training on BDNF and TrkB in the Hippocampus of Adult Male Rats. Armaghane danesh. 2014; 19 (5) :380-389
24. (24) Yarrow JF, White LJ, McCoy SC, Borst SE. Training augments resistance exercise induced elevation of circulating brain derived neurotrophic factor (BDNF). Neuroscience letters. 2010 Jul 26;479(2):161-5. [DOI:10.1016/j.neulet.2010.05.058]
25. (25) Goekint M, De Pauw K, Roelands B, Njemini R, Bautmans I, Mets T, Meeusen R. Strength training does not influence serum brain-derived neurotrophic factor. European journal of applied physiology. 2010 Sep 1;110(2):285-93. [DOI:10.1007/s00421-010-1461-3]
26. (26) Correia PR, Pansani A, Machado F, Andrade M, Silva AC, Scorza FA, Cavalheiro EA, Arida RM. Acute strength exercise and the involvement of small or large muscle mass on plasma brain-derived neurotrophic factor levels. Clinics. 2010;65(11):1123-6. [DOI:10.1590/S1807-59322010001100012]
27. (27) Parno A, Karimi E, Hosseini SA. The effect of resistance training on BDNF in mice plasma. Journal of knowledge and health. 2015; 10(3): 9-14.
28. (28) Twiss JL, Chang JH, Schanen NC. Pathophysiological mechanisms for actions of the neurotrophins. Brain Pathology. 2006 Oct;16(4):320-32. [DOI:10.1111/j.1750-3639.2006.00039.x]
29. (29) Erickson KI, Voss MW, Prakash RS, Basak C, Szabo A, Chaddock L, Kim JS, Heo S, Alves H, White SM, Wojcicki TR. Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences. 2011 Feb 15;108(7):3017-22. [DOI:10.1073/pnas.1015950108]
30. (30) Lu B, Chang JH. Regulation of neurogenesis by neurotrophins: implications in hippocampus-dependent memory. Neuron Glia Biology. 2004 Nov 1;1(4):377. [DOI:10.1017/S1740925X05000232]
31. (31) Griffin ÉW, Mullally S, Foley C, Warmington SA, O'Mara SM, Kelly ÁM. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiology & behavior. 2011 Oct 24;104(5):934-41. [DOI:10.1016/j.physbeh.2011.06.005]
32. (32) Savaskan E, Mueller H, Hoerr R, von Gunten A, Gauthier S. Treatment effects of Ginkgo biloba extract EGb 761® on the spectrum of behavioral and psychological symptoms of dementia: meta-analysis of randomized controlled trials. International psychogeriatrics. 2018 Mar;30(3):285-93. [DOI:10.1017/S1041610217001892]
33. (33) Weinmann S, Roll S, Schwarzbach C, Vauth C, Willich SN. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC geriatrics. 2010 Dec 1;10(1):14. [DOI:10.1186/1471-2318-10-14]
34. (34) Herrschaft H, Nacu A, Likhachev S, Sholomov I, Hoerr R, Schlaefke S. Ginkgo biloba extract EGb 761® in dementia with neuropsychiatric features: a randomised, placebo-controlled trial to confirm the efficacy and safety of a daily dose of 240 mg. Journal of Psychiatric Research. 2012 Jun 1;46(6):716-23. [DOI:10.1016/j.jpsychires.2012.03.003]

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