Volume 16, Issue 2 (Summer 2021)
Salmand: Iranian Journal of Ageing 2021, 16(2): 234-247 |
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Hasanvand B, Farhadi A. Effect of Combined Exercise and Ginkgo Biloba Supplementation for 8 Weeks on Brain-derived Neurotrophic Factor Level in Depressed Older Men. Salmand: Iranian Journal of Ageing 2021; 16 (2) :234-247
URL: http://salmandj.uswr.ac.ir/article-1-1893-en.html
URL: http://salmandj.uswr.ac.ir/article-1-1893-en.html
1- Department of Physical Education, Faculty of Humanities, Khorramabad Branch, Islamic Azad University, Iran. , hasanvand121@gmail.com
2- Department of Physical Education, Faculty of Humanities, Khorramabad Branch, Islamic Azad University, Iran.
2- Department of Physical Education, Faculty of Humanities, Khorramabad Branch, Islamic Azad University, Iran.
Abstract: (3995 Views)
Objectives: The current study aims to examine the effect of combined exercises and ginkgo biloba supplementation for 8 weeks on Brain-Derived Neurotrophic Factor (BDNF) level in depressed older men.
Methods & Materials: Forty depressed older men were randomly divided into four groups of exercise (n=10), supplementation (n=10), exercise + supplementation (n=10), and control (n=10). In the pre-test phase, blood samples were taken from the subjects. Then the participants in the exercise group performed combined exercises for eight weeks, 3 sessions per week. Those in the supplementation group, the subjects were given 80 mg of ginkgo biloba extract daily for eight weeks. In the exercise + supplementation group, the subjects received both interventions simultaneously. Blood samples were taken again 24 hours after the end of intervention. Collected data were analyzed using paired t-test, one-way ANOVA, and Bonferroni Post Hoc Test.
Results: Eight weeks of combined exercise alone, ginkgo biloba supplementation alone, and combined exercise and ginkgo biloba supplementation simultaneously significantly increased BDNF level in depressed older men (P<0.05). The increase in the BDNF level of subjects in the exercise + supplementation group was higher (84.78) compared to the exercise (74.37) and supplementation (72.20) groups.
Conclusion: Simultaneous use of combined exercises and ginkgo biloba supplementation can be used by geriatricians to improve brain function of depressed older men.
Methods & Materials: Forty depressed older men were randomly divided into four groups of exercise (n=10), supplementation (n=10), exercise + supplementation (n=10), and control (n=10). In the pre-test phase, blood samples were taken from the subjects. Then the participants in the exercise group performed combined exercises for eight weeks, 3 sessions per week. Those in the supplementation group, the subjects were given 80 mg of ginkgo biloba extract daily for eight weeks. In the exercise + supplementation group, the subjects received both interventions simultaneously. Blood samples were taken again 24 hours after the end of intervention. Collected data were analyzed using paired t-test, one-way ANOVA, and Bonferroni Post Hoc Test.
Results: Eight weeks of combined exercise alone, ginkgo biloba supplementation alone, and combined exercise and ginkgo biloba supplementation simultaneously significantly increased BDNF level in depressed older men (P<0.05). The increase in the BDNF level of subjects in the exercise + supplementation group was higher (84.78) compared to the exercise (74.37) and supplementation (72.20) groups.
Conclusion: Simultaneous use of combined exercises and ginkgo biloba supplementation can be used by geriatricians to improve brain function of depressed older men.
Keywords: Brain-derived neurotrophic factor, Combined exercise, Ginkgo biloba extract, Depression, Elderly
Type of Study: Applicable |
Subject:
gerontology
Received: 2019/09/05 | Accepted: 2020/11/29 | Published: 2021/07/01
Received: 2019/09/05 | Accepted: 2020/11/29 | Published: 2021/07/01
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