Volume 15, Issue 4 (Winter - In Press 2021)                   Salmand: Iranian Journal of Ageing 2021, 15(4): 8-8 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Alimoradzadeh R, Abbasi M A, Zabihi F, Mirmiranpour H. Effect of Anesthesia Techniques on Oxidant and Antioxidant Indices after Inguinal Hernia operation among Elderly Patients. Salmand: Iranian Journal of Ageing. 2021; 15 (4) :8-8
URL: http://salmandj.uswr.ac.ir/article-1-2053-en.html
1- MD, Geriatrician, Firoozabadi Clinical Research Development Unit (FACRDU), Iran University of Medical Sciences(IUMS), Tehran, Iran.
2- MD, Firoozabadi clinical Research Development Unit(FACRD), Iran university of Medical Sciences (IUMS), tehran, Iran.
3- MD, Resident of Geriatric Medicine, Firoozabadi clinical Research Development Unit (FACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran.
4- PhD, Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical of Sciences, Tehran, Iran. , H_mirmiranpoor@yahoo.com
Abstract:   (585 Views)
Objective: The effects of anesthesia thechniques and drugs on different body systems and organs, especially immune system in elderly patients who underwent operation, have always been investigated by investigators The aim of this study was to compare the effects of general anesthesia with isoflurane or spinal anesthesia with lidocaine on oxidative and antioxidant indices.
Materials & Methods: In this study, double-blind randomized clinical trial with parallel design was performed on elderly patients who underwent operation between 2018 and 2019. Patients were randomly divided into two groups (n = 35). In the first group patients received isoflurane gas and in the other group received lidocaine spinal anesthesia. Study sampling was performed in two stages; one day before (control sample) and one day after operation. In this study, AGEs, AOPP, MDA, LDL, FRAP, glutathione peroxidase, superoxide dismutase and catalase were measured.
Results: In this study and among patients of isoflorane group pre and postoperative measurement of Advanced Glycation End Products, Malonaldehyde, oxidized LDL, Ferric Reducing Ability of Plasma, Catalase, Glutathione Peroxidase and Superoxide Dismutase had significant difference. For patients in the lidocaine group, this difference was observed for the indices including Malonaldehyde, oxidized LDL, Catalase and Superoxide Dismutase.
Conclusion: With regards to positive effects of anesthetic gases such as isflorane on oxidative and antioxidant indices in elderly patients,  these results should be considered in the selection of anesthesia methods and drugs for the elderly patient underwent operation.
Type of Study: Research | Subject: Geriatric
Received: 2020/07/05 | Accepted: 2020/10/19 | Published: 2021/02/24

1. [1] Steven L. Shafer, The Pharmacology of anesthetic drugs in elderly patients, Anesthesiology Clinics of North America, 2000 (18), 1, 1-29 [DOI:10.1016/S0889-8537(05)70146-2]
2. [2] J.E. PEACOCK, R.P. LEWIS, C.S. REILLY, W.S. NIMMO, Effect of different rates of infusion of Propofol for induction of anesthesia in elderly patients, British Journal of Anaesthesia, 1990, (65), 3, 346-352, [DOI:10.1093/bja/65.3.346] [PMID]
3. [3] Niedermeyer E, Silva F. Electroencephalography: Basic Principles, Clinical Applications, and Related Fields. Lippincott Williams & Wilkins; 2005.
4. [4] Pharmacists. TASoH-S. Lidocaine Hydrochloride (Antiarrhythmic). The American Society of Health-System Pharmacists; 2015.
5. [5] Ceylan BG, Nazıroğlu M, Uğuz AC, Barak C, Erdem B, Yavuz L. Effects of vitamin C and E combination on element and oxidative stress levels in the blood of operative patients under desflurane anesthesia. Biological Trace Element Research 2011; 141 (1-3): 16-25. [DOI:10.1007/s12011-010-8712-3] [PMID]
6. [6] Wilson WC, Swetland JF, Benumof JL, Laborde P, Taylor R. General anesthesia and exhaled breath hydrogen peroxide. Anesthesiology 1992; 76 (5):703-10. [DOI:10.1097/00000542-199205000-00007] [PMID]
7. [7] Ceylan BG, Yilmaz F, Eroglu F, Yavuz L, Gulmen S, Vural H. Oxidant and antioxidant activities of different anesthetic techniques. Saudi Medical Journal 2009; 30 (3):371-6.
8. [8] Eroglu F, Yavuz L, Ceylan BG, Yılmaz F, Eroglu E, Delibas N, et al. New volatile anesthetic, desflurane, reduces vitamin E level in blood of operative patients via oxidative stress. Cell Biochemistry and Function 2010; 28 (3):211-216. [DOI:10.1002/cbf.1641] [PMID]
9. [9] Kulacoglu H, Ozdogan M, Gurer A, Ersoy E, Onder AD, Duygulu SD, et al. Prospective comparison of local, spinal, and general types of anaesthesia regarding oxidative stress following Lichtenstein hernia repair. Bratislavske Lekarske Listy 2007; 108 (8):335-339.
10. [10] Sivaci R, Kahraman A, Serteser M, Sahin DA, Dilek ON. Cytotoxic effects of volatile anesthetics with free radicals undergoing laparoscopic surgery. Clinical Biochemistry 2006; 39 (3):293-8. [DOI:10.1016/j.clinbiochem.2006.01.001] [PMID]
11. [11] Mohaghegh T, Yazdi B, Norouzi A, Fateh Sh, Modir H, Abolfazl Mohammadbeigi A. Effect of intravenous anesthesia with propofol versus isoflurane inhalation anesthesia in postoperative pain of inguinal herniotomy: a randomized clinical trial. Medical Gas Research 2017; 7 (2):86-92. [DOI:10.4103/2045-9912.208511] [PMID] [PMCID]
12. [12] Sayed S, Idriss NK, Sayyedf HG, Ashry AA, Rafatt DM, Mohamed AO, Blann AD. Effects of propofol and isoflurane on haemodynamics and the inflammatory response in cardiopulmonary bypass surgery. British Journal of Biomedical Science 2015; 72 (3):93-101. [DOI:10.1080/09674845.2015.11666803] [PMID]

Add your comments about this article : Your username or Email:

Send email to the article author

© 2021 All Rights Reserved | Iranian Journal of Ageing

Designed & Developed by : Yektaweb