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1- Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran. , assadiasl@sina.tums.ac.ir
2- Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
2- Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Abstract: (1192 Views)
Objectives: Considering the increase in the old adult population and age-related disorders there is a need for strategies to reduce the complications of aging. Senolytic drugs might improve the function of tissues and organs in elderly people by destroying senescent cells. In this review, we aimed to introduce different categories of senolytic drugs.
Materials and methods: The keywords “senolytic” and “senolysis” were searched in PubMed, Scopus, and Google Scholar search engines. All original, review, and systematic review articles published between 2015 and 2023 were studied systematically. After the validation of data, 50 out of 108 articles were selected and a summary of classifications and results was provided.
Results: Currently, 12 categories of senolytics, including kinase inhibitors, natural polyphenols, Bcl2 protein family inhibitors, P53 stabilizers, heat shock protein inhibitors, BET protein family inhibitors, cardiac steroids, PPARα agonists. , antibiotics, integrase inhibitors, caloric restriction and CAR-T cells have been introduced that are under study in different phases of preclinical or clinical research.
Conclusion: Considering the aging of the population, one of the strategies to deal with the debilitating effects of old age is senolytics, which can eliminate senescent cells with unfavorable function. The most studied categories with promising results include kinase enzymes and polyphenols, but novel strategies such as specific targeting of senescent cells with CAR-T cells are being developed.
Materials and methods: The keywords “senolytic” and “senolysis” were searched in PubMed, Scopus, and Google Scholar search engines. All original, review, and systematic review articles published between 2015 and 2023 were studied systematically. After the validation of data, 50 out of 108 articles were selected and a summary of classifications and results was provided.
Results: Currently, 12 categories of senolytics, including kinase inhibitors, natural polyphenols, Bcl2 protein family inhibitors, P53 stabilizers, heat shock protein inhibitors, BET protein family inhibitors, cardiac steroids, PPARα agonists. , antibiotics, integrase inhibitors, caloric restriction and CAR-T cells have been introduced that are under study in different phases of preclinical or clinical research.
Conclusion: Considering the aging of the population, one of the strategies to deal with the debilitating effects of old age is senolytics, which can eliminate senescent cells with unfavorable function. The most studied categories with promising results include kinase enzymes and polyphenols, but novel strategies such as specific targeting of senescent cells with CAR-T cells are being developed.
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