Objectives: The aim of this study was to compare of waist circumference with metabolic syndrome ,as a predictor insulin resistance in agroup of elderly population.

Methods & Materials: In a cross-sectional study among 225 elderlyaged 60 year old and more whose clinical data were complete, 94 subjects (42 males and 52 females) who were able to sign the consent form Mini Mental stat Examination>20 and wanted to participate in studyentered the study. Insulin sensitivity was determined by using Homeostasis Model Assessment index. Insulin resistance was defined as topquartile of Homeostasis Model Assessment.

Results: Waist Circumference and Homeostasis Model assessment andHomeostasis Model Assessment index were highly positively correlated in both sexes. The optimal waist circumference was 94.5 cm for men and 90.5 cm for women. `The high sensitivity and specificity of Waist Circumference and Homeostasis Model assessment in males (0.80 & 0.84) indicates the proportion of Insulin Resistance which are correctlyidentified all non-IR males as such.

Conclusion: In this study 94.5 cm determined as cut-off for insulin resistance index in males. It seems that optimal Waist Circumference andHomeostasis Model assessment determinination in Iran warrants further study in a larger sample of metabolic syndrome subjects.